In the world of performance materials, innovation rarely arrives with dramatic announcements. More often, it emerges quietly—embedded in molecular architecture, hidden within polymer backbones that enable everyday products. One such…
Suzuki–Miyaura (SM) cross-coupling is the backbone of modern pharmaceutical and agrochemical manufacturing. However, as global regulatory and cost pressures mount, the industry is shifting away from traditional methods toward sustainable…
Evolution & Challenges Faced for Suzuki Miyaura From bench staple to industrial workhorse.
The Suzuki–Miyaura (often just “Suzuki”) cross-coupling — coupling an organoboron reagent with an aryl/alkenyl (pseudo)halide under palladium…
Introduction
In the world of advanced chemical synthesis, few reactions have had as much lasting impact as the Stille reaction. Developed by American chemist John K. Stille in the late…
Introduction
Struggling with challenging cross-coupling reactions involving sensitive functional groups? In modern organic synthesis, efficient carbon–carbon (C–C) bond formation remains one of the most essential yet complex transformations. Among…
Introduction
In the realm of organic synthesis, forming carbon–carbon bonds efficiently is critical for pharmaceuticals, agrochemicals, and specialty chemicals. Kumada coupling, discovered by Makoto Kumada in the 1970s, is one…