1-Hydroxybenzotriazole (HObt) In NMP
1-Hydroxybenzotriazole in NMP
Specifications of 1-Hydroxybenzotriazole (HObt) in NMP
- Assay: 22% – 24%
Physical & Chemical Properties
| CAS Number | 123333-53-9 |
| Molecular Formula | C6H5N3O |
| Molecular Weight | 135.12 g/mol |
| Appearance | Clear Colorless to pale yellow Liquid |
Applications of 1-Hydroxybenzotriazole (HOBT)
HOBt in NMP is used as an effective additive in coupling reactions, where it helps suppress racemization and ensures higher purity of the final product.
It is suitable for application in both solid-phase and solution-phase peptide synthesis.
Applied in the synthesis of active pharmaceutical ingredients (APIs) and intermediates and anticancer agents such as Ubenimex.
Plays a role in the synthesis of heterocycles, esters, and complex organic building blocks for high-value chemical applications.
Advantages of 1-Hydroxybenzotriazole (HOBT)
Since the material is already in liquid form, workers are not exposed to the irritating or allergenic effects.
Using HOBT in solution helps avoid the risk of dust-related explosions that may occur with powdered HOBT.
Factories do not need to obtain special permits for the storage of flammable solids, as HOBT in NMP is already stabilized in liquid form.
The solution can directly replace HOBT powder in established production systems.